What good is CRISPR if it can't get where it needs to go? WIRED

Gold nanoparticles effectively deliver CRISPR to mouse models of DMD  Fierce Biotech

Nonviral CRISPR Delivery a Success   The Scientist

CRISPR’s breakthrough problem     Chemical & Engineering News

Scientists Establish New Nonviral Method for CRISPR Using Gold Nanoparticles   Futurism

Gold nanoparticle used to replace virus in new CRISPR approach

Genetic mutation in mice treatable with CRISPR-Gold gene-editing technology   The Daily Californian

'CRISPR-Gold' fixes Duchenne muscular dystrophy mutation in mice   Medical Xpress

Gene activation therapy prevents liver damage in mice   Science 


October 2018

Nature Biomedical Engineering,

Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours.


Lee, B., Lee, K., Panda, S., Gonzales-Rojas, R., Chong, A., Bugay, V., Park, HM., Brenner, R., Murthy, N., Lee, HY.  Nature Biomedical Engineering, 2018. Read More.

Lee, K., Conboy, M., Park, HM., Jiang, F., Kim, HJ., Dewitt, M., Mackley, V., Chang, K., Rao, A.,  Skinner, C., Shobha, T., Liu, H., Huang, WH., Lan, F., Bray, N., Li, S., Corn, J., Kataoka., K., Doudna, J., Conboy, I., Murthy, N. Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homologous directed DNA repair. Nature Biomedical Engineering, 2017. Read more. 

Lee, K., Mackley, V., Rao, A., Chong, A., Dewitt, M., Corn, J., Murthy, N. Synthetically modified guide RNA and donor DNA are versatile platform for CRISPR-Cas9 engineering. eLife, 2017. Read more.


Papers on protein delivery

Lee, K., Rafi, M., Feng, X., Tang, R., Lingampalli, N., Aran, K., Murthy, N. In vivo delivery of transcription factors with multifunctional oligonucleotides. Nature Materials, 2015. Read more.   

Aran, K., Choojian, M., Paredes, J., Rafi, M., Lee, K., Kim, A., An, J., Yau, J., Chum, H., Conboy, I., Murthy, N., and Liepmann, D. An oral microjet vaccination system elicits antibody production in rabbits. Science Translational Medicine, 2017. Read more.

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